Banning Gray Lary, MD
Coronary Artery Research

From his early days in medical school, Banning Gray Lary became increasingly dedicated to independent research on the human vascular system, especially the coronary arteries. With age, blockage (atherosclerosis) of the coronary arteries (vessels which return oxygenated blood to feed the heart muscle from the aorta), coronary artery disease can occur - a leading cause of death among American males and females. Realizing that heart transplants and the use of artificial hearts were impractical due to the complexity of the surgery, the rate of rejection and scarcity of available hearts, Lary sought to find ways to repair or replace coronary arteries and thus extend the lifespan of human patients. (Watch cutting edge graphic animation of Coronary Artery Stenosis and Dilation Technique (CASD).

Cornary Stenosis due to Atherosclerosis

Research Milestones:

(see publications)

1952: Maintenance of Life with Intravenous Oxygen

First demonstration that animals could be kept alive breathing pure nitrogen sustained by very small bubbles of oxygen delivered via intravenously. Presented to the American College of Surgeons. Important step toward the development of the heart-lung machine.

1955: Traumatic Axillary Aneurysm of Thirteen Years' Duration - Use of Venous Shunt

First operation of this type and of contusion shock for cardiac arrest. Unusual case where arterial aneurysm had many causes in single individual: gunshot wound trauma, atherosclerosis with hypertension and syphilis. The large axillary aneurysm was by-passed with a segment of vein as a method of treatment. In this work was described a cardiac arrest which occurred at the onset of anesthesia and where the heart was restarted by a sharp blow to the sternum.

1955: Paradoxical Aortogram in a Dissecting Aortic Aneurysm

First translumbar aortogram performed in a dissecting aneurysm where the false channel was injected with the contrast media. The physiological, anatomical and pathologic parameters were correlated with the radiographic findings.

1956: Experimental Use of Stainless Steel Mesh for Replacement of Arterial Segments

Segments of the aorta were replaced with tubes made from stainless steel wire mesh - seminal research that predated today's use of stainless steel stents now placed inside many arteries, including ruptured, or threatening to rupture, aneurysms.

1963: Effect of Endocardial Incisions on Myocardial Blood Flow

First description of multiple perforations by needle through the myocardium into ventricular cavity in the effort to increase blood flow to the myocardinal syncitium - 30 years prior to transmyocardial revascularization (TMR and EMR) in the beating heart.

1966: Onlay Vein Graft for the Correction of Coronary Artery Obstruction

First published "concept" of aorto-coronary by-pass and attachment of homologous vein to epicardium overlying the coronary artery to effect coronary artery enlargement - in the beating heart.

1966: Method for Increasing the Diameter of Long Segments of the Coronary Artery

First description of longitudinally opening the coronary artery beneath the epicardium to enlarge the arterial lumen - in the beating heart.

1966: A Method for Creating a Coronary-Myocardinal Artery

First surgical operative technique for incising the coronary artery into the myocardium - in the beating heart.

1966: A Method to Create and Correct Stenosis of the Coronary Artery

First suture stenosis of the coronary artery corrected by longitudinal incision of the endolumen - in the beating heart.

1969: Coronary Artery Resection and Replacement by a "Blood Conduit"

First to demonstrate a conduit could be established between the two cut ends of a coronary artery from which a segment had been removed - in the beating heart.

1969: Myocardial Revascularization Experiments using the Epicardium

First to demonstrate the anatomical potential to perform various operative procedures for myocardial revascularization - in the beating heart.

1974: Experimental Vein Angioplasty of the Circumflex Coronary Artery

First to attach a segment of vein to the circumflex coronary artery using an arterial perfusing shunt from a peripheral artery and demonstrating post operative normal blood flow through the artery - in a beating heart.

1980: Coronary Artery Incision and Dilation

First to longitudinally incise the endolumen and dilate a stenosis of a coronary artery - in the beating heart.

This seminal research culminated in the development of many surgical inventions that have been approved by the FDA and are now being used to save lives in operating rooms around the world. (Watch SpecBoard video.)

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